I used to work in a large format output service. It's perfectly normal to build your file at some easy-to-use percentage of the finished size (essential, in fact, after you get over the maiximum dimensions for PDF or .indd), such as one-half or one-quarter scale, and let the printer scale it up on output. Just be sure you ask the printer what the resoultion of your raster images should be at print size and make sure they have enough resolution at the size you create your file to maintain the target resolution after scaling.
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